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Description
human bcrp vesicle kit hek293Das Human BCRP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient das Breast Cancer Resistance Protein (BCRP ABCG2) berexprimieren. Das Kit ermglicht ATP abhngige Substrattransportstudien im High Throughput Format und ist konform mit den FDA (2017) und EMA (2013) Leitlinien zur Charakterisierung von Arzneimittelwechselwirkungen (DDI). Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich ber SeamlessBio. Transporter
Das Human BCRP Vesicle Kit enthält Inside-out-Membranvesikel aus HEK293-Zellen, die transient das Breast Cancer Resistance Protein (BCRP / ABCG2) überexprimieren. Das Kit ermöglicht ATP abhängige Substrattransportstudien im High-Throughput-Format und ist konform mit den FDA (2017)- und EMA (2013)-Leitlinien zur Charakterisierung von Arzneimittelwechselwirkungen (DDI).
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
Transporter-Profil
Name: BCRP, Breast Cancer Resistance Protein, ABCG2, ATP-bindende Kassette Unterfamilie G Mitglied 2
Gen: ABCG2
ATP/AMP-Ratio: >10 (garantiert)
Gewebsexpression: Plazenta, Stammzellen, Prostata, Dünndarm, Gehirn, Dickdarm, Leber, Brustdrüse, Niere
Bekannte Substrate: Estron-3-Sulfat (E1S), Methotrexat, Irinotecan, Pantoprazol, Rosuvastatin, Topotecan, Chlorothiazid, Mitoxantron, SN-38, Glibenclamid
Kit-Inhalt (100 Reaktionen)
- Vesikel-Vial (100 Reaktionen), BCRP-überexprimierende
- HEK293-abgeleitete Vesikel
- AMP-ATP-Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Anwendungen
- Identifikation von Efflux-Transporter-Substraten
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Inhibitionsstudien (IC50-Bestimmung)
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
Der vesikuläre Transportassay mit BCRP-Vesikeln wird im FDA Drug
Interaction Guidance (2017) und in der EMA-Leitlinie zur Untersuchung von
Arzneimittelinteraktionen (2013) für die Charakterisierung
transporter-vermittelter DDI in der Arzneimittelentwicklung empfohlen.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
Verwandte Produkte
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
- Human Pgp Vesicle Kit (C4PVK010) – für parallele P-gp-Efflux-Messung
- ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
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4.1 ★★★★★
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Product Reviews
★★★★★ 1
To small
Gem Type: no gemstone, Item Display Length: 6.5 Inches
Very tiny you can barely see it. I would not recommend it.
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Reviewed in the United States on December 9, 2024
★★★★★ 5
El producto esta tal como se describe
Exelente producto
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Reviewed in the United States on March 27, 2026
★★★★★ 1
Tarnishes
Tarnished after just 1 month. For the price that shouldn’t happen
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Reviewed in the United States on February 6, 2026
★★★★★ 5
Bellísima
Es muy delicada y luce muy bien
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Reviewed in the United States on October 19, 2025
★★★★★ 5
Cute and stylish bracelet
I recently purchased the Sterling Silver 14K Gold-Plated Clover Bracelet with the Mother of Pearl four-leaf charm, and I couldn't be happier with my choice! First off, the design is just lovely; the combination of the silver and gold plating adds a touch of elegance, while the charm really stands out with its beautiful, iridescent finish. It catches the light beautifully and feels both delicate and durable at the same time.
I was drawn to this bracelet because it’s not just a piece of jewelry; it symbolizes good luck, which I thought would make a nice gift for a friend. When I received it, I realized it would also make a fantastic addition to my own collection! The size is just right, and it’s comfortable to wear all day long without any irritation, which can sometimes be a concern with bracelets.
My friend loved it and appreciated the thoughtful gesture. It’s the kind of gift that feels personal and meaningful. Overall, I’d say this bracelet is a charming piece that combines style and a bit of luck, making it a wonderful treat for yourself or a special gift for someone else. I highly recommend it!
🌟 1 Star: I do not recommend this product at all, it has serious flaws and needs to be refined before I can recommend purchasing it
🌟🌟 2 Stars: This product may have some major flaws, but there is still some good things about it. (I.E. Price)
🌟🌟🌟 3 Stars: This product only has minor flaws or bad instructions, and I can still recommend buying it in most conditions.
🌟🌟🌟🌟 4 Stars: This product has very few flaws and I recommend purchasing it.
🌟🌟🌟🌟🌟 5 Stars: Exceptional product, minimal or no flaws.
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Reviewed in the United States on September 14, 2025