SKU: 1538953491

FITC-Labeled ICAM-1/CD54 Fc Chimera Protein, Human

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Description

FITC-Labeled ICAM-1/CD54 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms BB2,CD54 antigen,CD54,cell surface glycoprotein P3. 58,human rhinovirus receptor,ICAM1,ICAM 1,intercellular adhesion molecule 1 (CD54) Accession P05362 1 Amino Acid Sequence Gln28 Glu480 with hIgG1 Fc Tag at C Terminus Expression System HEK293 Molecular Weight 49 72kDa (Reducing) Conjugation FITC Tag Human IgG1 Fc Physical Appearance Liquid Storage Buffer PBS, pH7. 4 Stability & Storage 12 months from date

Product Specification


Species Human
Synonyms BB2,CD54 antigen,CD54,cell surface glycoprotein P3.58,human rhinovirus receptor,ICAM1,ICAM-1,intercellular adhesion molecule 1 (CD54)
Accession P05362-1
Amino Acid Sequence

Gln28-Glu480 with hIgG1 Fc Tag at C-Terminus

Expression System HEK293
Molecular Weight

49-72kDa (Reducing)

Conjugation FITC
Tag Human IgG1 Fc
Physical Appearance Liquid
Storage Buffer

PBS, pH7.4

Stability & Storage

· 12 months from date of receipt stored at -20 to -80℃.
· 1 week, 2 to 8℃ under sterile conditions
· Recommend to aliquot the protein into smaller quantities for optimal storage.
· Please avoid repeated freeze-thaw cycles.

Reference

1、Gu H F. et al. (2013) Association of intercellular adhesion molecule 1 (ICAM1) with diabetes and diabetic nephropathy. Front Endocrinol. 3: 179.
2、 Williams M R. et al. (2013) ICAM1 ligation‐induced transmigratory complex formation regulates leukocyte transendothelial migration. FASEB J. 27(S1): 57.5-57.5.

Background

ICAM-1 is a cell surface glycoprotein expressed at a low basal level in immune, endothelial (EC) and epithelial cells, but is up-regulated in response to inflammatory stimulation. The function of ICAM-1 has been best studied in leukocyte transendothelial migration (TEM), where ICAM-1 regulates leukocyte rolling and adhesive interactions with the vessel wall, and guides leukocyte crossing of the endothelial layer. More recently, functional studies identified several new roles of ICAM-1 in epithelial injury-resolution responses, innate and adaptive immune responses in inflammation, and tumorigenesis.

Guidelines

Following recommended dosage for experiments strictly. If the population clustering is not distinct, the recommended dosage could be appropriately increased by 2–5 folds.

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SKU: 1538953491

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