Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 13 - Jul 18
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Biotin Syrian hamster Anti-Mouse CD28 Antibody (S-R515)Product Specification Host Syrian Hamster Antigen CD28 Synonyms T cell specific surface glycoprotein CD28 Location Cell membrane Accession P31041 Clone Number S R515 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 0. 5 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from
Product Specification
| Host | Syrian Hamster |
| Antigen | CD28 |
| Synonyms | T-cell-specific surface glycoprotein CD28 |
| Location | Cell membrane |
| Accession | P31041 |
| Clone Number | S-R515 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Ms |
Background
CD28 is a critical costimulatory receptor expressed on the surface of T cells, particularly on CD4+ and CD8+ T cells, and plays a pivotal role in T cell activation, proliferation, and survival. It is a homodimer of 44kDa subunits, each containing a single immunoglobulin-like extracellular domain, and is part of the Ig superfamily. CD28 interacts with its ligands, CD80 (B7-1) and CD86 (B7-2), which are predominantly found on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. The engagement of CD28 with these ligands is essential for providing the second signal required for full T cell activation, which complements the antigen-specific signal delivered by the T cell receptor (TCR). CD28 signaling leads to the upregulation of IL-2 and its receptor expression, enhances T cell proliferation, and promotes the production of various cytokines, including IL-4, IL-5, IL-13, IFN-γ, and TNF. It also plays a role in the differentiation of T cells into memory phenotypes and in maintaining immune homeostasis. The absence of CD28 signaling results in reduced T cell survival and impaired antibody responses to T-dependent antigens. CD28 is thus a key regulatory point for successful B cell, macrophage, and cytotoxic T cell responses.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy