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Description
hnRNP U Recombinant Rabbit mAb (S-2375-23)Product Specification Host Rabbit Antigen hnRNP U Synonyms Heterogeneous nuclear ribonucleoprotein U; GRIP120; Nuclear p120 ribonucleoprotein; Scaffold attachment factor A (SAF A); p120; pp120; C1orf199; HNRPU; SAFA; U21. 1; HNRNPU Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q00839 Clone Number S 2375 23 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, 293T, K562, NIH
Product Specification
| Host | Rabbit |
| Antigen | hnRNP U |
| Synonyms | Heterogeneous nuclear ribonucleoprotein U; GRIP120; Nuclear p120 ribonucleoprotein; Scaffold-attachment factor A (SAF-A); p120; pp120; C1orf199; HNRPU; SAFA; U21.1; HNRNPU |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q00839 |
| Clone Number | S-2375-23 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, 293T, K562, NIH/3T3, mouse liver, mouse brain, C6, rat brain, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:50000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:1000-1:5000 | Hu, Ms, Rt |
Background
Heterogeneous nuclear ribonucleoprotein U (HNRNPU, also called scaffold attachment factor A/SAF-A) is a ~120 kDa, ubiquitously expressed nuclear protein that functions as a multifunctional hub integrating RNA metabolism, chromatin organization and transcriptional control: it binds both RNA and AT-rich scaffold/matrix attachment region DNA through N-terminal SAP and C-terminal RGG RNA-binding domains to organize 3-D chromatin architecture, regulate alternative pre-mRNA splicing by controlling U2 snRNP maturation and Cajal body morphology, stabilize or destabilize specific mRNAs via 3′-UTR interactions, and modulate RNA polymerase II elongation together with cofactors like p300/PCAF; its actions are essential for heart development (cardiac-specific deletion causes lethal dilated cardiomyopathy with widespread splicing defects), early neuronal differentiation and brain function (mutations produce intellectual disability, autism spectrum disorder and epilepsy), and it also participates in X-chromosome inactivation, telomere maintenance and protein homeostasis by acting as a pseudosubstrate for SCF ubiquitin ligases[^8].
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