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Description
Biotinylated IFN-alpha/beta R1 His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms IFNAR1,IFRC,IFNAR,CRF2 1,IFNAR 1,IFN R 1 Accession P17181 1 Amino Acid Sequence Lys28 Lys436 with His&Avi Tag at the C Terminus Expression System HEK293 Molecular Weight 72 95kDa (Reducing) Purity 95% by SDS PAGE & > 90% SEC HPLC Conjugation Biotin Tag Avi Tag, His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the
Product Specification
| Species | Human |
| Synonyms | IFNAR1,IFRC,IFNAR,CRF2-1,IFNAR-1,IFN-R-1 |
| Accession | P17181-1 |
| Amino Acid Sequence | Lys28-Lys436 with His&Avi Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 72-95kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 90% SEC-HPLC |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Constantinescu SN, Croze E, Wang C, Murti A, Basu L, Mullersman JE, Pfeffer LM. Role of interferon alpha/beta receptor chain 1 in the structure and transmembrane signaling of the interferon alpha/beta receptor complex. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9602-6. |
Background
The interferon-α/β receptor alpha chain (IFNAR1, CD118) is a single-pass transmembrane protein that belongs to the class II cytokine receptor family and contains four fibronectin type-III domains; together with IFNAR2 it forms the type I interferon receptor. Serving as the high-affinity binding site for IFN-α/β, IFNAR1 can also transduce IFN-β signals independently and modulate—sometimes suppress—the Jak-STAT pathway, thereby acting as a critical on/off switch in innate antiviral immunity. Its expression level or mutation at Tyr466 directly affects STAT phosphorylation efficiency, linking IFNAR1 to chronic viral infections, autoimmune disorders and interferon therapy resistance, making it a key biomarker for assessing IFN efficacy and developing targeted immunomodulatory drugs.
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