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Description
KRAS Recombinant Rabbit mAb (S-R291)Product Specification Host Rabbit Antigen KRAS Synonyms GTPase KRas, K Ras 2, Ki Ras, c K ras, c Ki ras, KRAS2, RASK2 Location Cytoplasm, Cell membrane Accession P01116 Clone Number S R291 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ICFCM, IP Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | KRAS |
| Synonyms | GTPase KRas, K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, KRAS2, RASK2 |
| Location | Cytoplasm, Cell membrane |
| Accession | P01116 |
| Clone Number | S-R291 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC, ICFCM, IP |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:2000 | null |
| ICC | 1:500 | null |
| ICFCM | 1:50 | null |
| IP | 1:50 | null |
Background
The K-Ras protein is a GTPase, a class of enzymes which convert the nucleotide guanosine triphosphate (GTP) into guanosine diphosphate (GDP). In this way the K-Ras protein acts like a switch that is turned on and off by the GTP and GDP molecules. To transmit signals, it must be turned on by attaching (binding) to a molecule of GTP. The K-Ras protein is turned off (inactivated) when it converts the GTP to GDP. When the protein is bound to GDP, it does not relay signals to the nucleus. Like other members of the ras subfamily of GTPases, the K-Ras protein is an early player in many signal transduction pathways. Once it is allosterically activated, it recruits and activates proteins necessary for the propagation of growth factors, as well as other cell signaling receptors like c-Raf and PI 3-kinase.
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