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Description
APC Mouse Anti-Human CD45RA Antibody (S-R377)Product Specification Host Mouse Antigen CD45RA Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; CD45; PTPRC Location Cell membrane, Synapse Accession P08575 Clone Number S R377 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation APC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin
Product Specification
| Host | Mouse |
| Antigen | CD45RA |
| Synonyms | Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; CD45; PTPRC |
| Location | Cell membrane, Synapse |
| Accession | P08575 |
| Clone Number | S-R377 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD45RA is a splice variant of the CD45 protein, encoded by the PTPRC gene, and is a transmembrane glycoprotein with receptor-type protein tyrosine phosphatase activity. It contains the exon 4 in its structure, which distinguishes it from other CD45 isoforms like CD45RO. CD45RA is predominantly expressed on naïve T cells, indicating their potential for activation and differentiation into effector and memory T cells. Its unique extracellular domain, composed of fibronectin type III repeats, is crucial for modulating intracellular signaling pathways, particularly the T-cell receptor (TCR) signaling cascade. The presence of CD45RA on proliferating cells also serves as a marker for tracking clonal expansions in immune responses.
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4.6 ★★★★★
Based on 484 reviews
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Product Reviews
★★★★★ 4
Fun, enticing dog toy. As stated in description it won’t hold up for aggressive chewers
Color: Blue
Rating this based on description. My dog loved this toy. It was smaller than I had pictured in my head, but that was on me. I did read the description ahead of time, which clearly states this is not for aggressive chewers. My dog is trained not to rip toys apart so I wanted to give this a shot, but i guess just her jaw strength and teeth were too much. She carried it everywhere. I turned it on periodically. The movements are small, but enough for her to be captivated with the toy. It did mostly survive for about a day before I needed to take it away due to the Velcro opening. Once it started to pull apart she did chew a piece of the Velcro off. It might be helpful with a flap over design covering the Velcro. I have a singing Santa decoration like this where the Velcro is covered up and I have to pull it back a little to get to the Velcro opening. The gaps on the sides of the closure are a bit to large making it tempt my dog to pull and open it up.
I wish there was a more durable option that could hold up to aggressive chewers, but this product was clear about that in the description. I think the opening to the batteries could use some improvement. Granted I do not have the perfect answer to fix this, but I am also not a toy designer.
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Reviewed in the United States on April 19, 2026
★★★★★ 5
My Dog Went Crazy Over This Electric Octopus Toy!
Color: Blue
I was worried sick my fur kid would be super bored home alone while I work, so when I stumbled on this electric octopus toy, I grabbed it right away—and it’s way better than I expected! Let’s start with the quality: the plush fabric feels soft and squishy but so sturdy. It’s not the cheap kind that sheds fur if you tug it, and the stitches are nice and neat. My dog loves chewing on toys, and he’s been playing with this for almost two weeks now—no pilling, no fraying. The durability’s seriously on point.
Using it is totally hassle-free, too. It was already charged right out of the box—I just pressed the little button on the side, and it started moving. It has two modes: slow mode makes the octopus wiggle gently, like it’s crawling slowly. Fast mode? It wiggles and scurries around, and the speed’s perfect—my dog can keep up but still has to work a little. When he first saw it, he circled it three times, sniffed it, then backed up right away. He stared at it all cautious, even hid under the couch to spy on it for a bit. That little look was so funny and cute, I couldn’t stop laughing.
Now they’re total best buds! Every morning, as soon as I turn the toy on, he runs over with his little bed in his mouth and plops down next to it, waiting for it to move. Sometimes the octopus crawls under the table, and he’ll paw at it for ages. If he can’t reach it, he’ll look up and bark at me like, “Hey, help me get it!” Watching him chase it around, jumping to pounce—his tail wags like a little flag the whole time. It makes the house feel so much livelier, and I don’t have to stress about him being lonely when he’s home alone anymore.
Quick tips for all you fellow pet parents: First, the toy makes a tiny motor hum when it moves. It’s not loud, but if your dog’s super skittish or scared of small noises, give him a few days to get used to it. Second, always keep an eye on him while he plays. Mine tried to bite off one of the octopus’s tentacles once—I stopped him just in time. The toy has a motor inside, so you gotta make sure he doesn’t swallow any small parts. Oh, and the plush cover zips off! If it gets dirty, just throw it in warm water, wash it, and once it’s dry, it looks good as new. Super easy to clean.
Overall, this electric octopus toy’s the best pet buy I’ve made lately. Great quality, no hassle to use, and it keeps my dog entertained for hours. Every time I see my fur kid’s happy little face while he plays, I think, “Man, this was totally worth the money.” Def recommend it to anyone who wants a fun little buddy for their dog!
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Reviewed in the United States on August 26, 2025
★★★★★ 5
Good quality and safe for my pet! Lots of fun to play with!
Color: Blue
Worth buying for your pet! My American Bulldog wouldn’t leave it alone !
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Reviewed in the United States on June 11, 2026
★★★★★ 4
Super fun but fabric not durable for rough play.
Color: Blue
My dog absolutely love this, but the octopus cloth fell apart within the first day. He doesn’t usually play rough with his toys, but he was able to shred this octopus fabric very easily. He was very passionate in his playfulness and he’s a big dog, but he was able to put massive holes in the fabric within the first hour of play. The Ball still works, however so hopefully we can find another toy to stick it in.
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Reviewed in the United States on May 8, 2026
★★★★★ 5
My dog's favorite toy to date
Color: Blue
Heavy duty material that my dog has not destroyed. The vibrating ball inside is made of hard plastic, so beware if your dog likes to shake their toys, it definitely hurts to get whacked by this. The velcro keeping the ball inside is also heavy duty and takes a lot of strength to open. All in all, its a great toy and one of my dog's favorites.
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Reviewed in the United States on June 10, 2026