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Description
Bcl-xL His Tag Protein, HumanProduct Specification Species Human Synonyms Bcl 2 Like Protein 1,Bcl2 L 1,Apoptosis Regulator Bcl X,BCL2L1,BCL2L,BCLX Accession Q07817 Amino Acid Sequence Met1 Phe210, with C 10*His Expression System HEK293 Molecular Weight Theoretical: 25. 2kDa Actual: 29kDa Purity >95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer 0. 2M PBS, pH7. 4. Reconstitution Reconstitute no more than 1
Product Specification
| Species | Human |
| Synonyms | Bcl-2-Like Protein 1,Bcl2-L-1,Apoptosis Regulator Bcl-X,BCL2L1,BCL2L,BCLX |
| Accession | Q07817 |
| Amino Acid Sequence | Met1-Phe210, with C-10*His |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:25.2kDa Actual:29kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
B-cell lymphoma-extra large (Bcl-xL) is a transmembrane molecule in the mitochondria. It is a member of the Bcl-2 family of proteins, and acts as an anti-apoptotic protein by preventing the release of mitochondrial contents such as cytochrome c, which leads to caspase activation and ultimately, programmed cell death. Bcl-xL dysfunction in mice can cause ineffective production of red blood cells, severe anemia, hemolysis, and death. This protein has also been shown as a requirement for heme production[6] and in erythroid lineage, Bcl-xL is a major survival factor responsible for an estimated half of the total survival "signal" proerythroblasts must receive in order to survive and become red cells. Similar to other Bcl-2 family members, Bcl-xL has been implicated in the survival of cancer cells by inhibiting the function of p53, a tumor suppressor. In cancerous mouse cells, those which contained Bcl-xL were able to survive while those that only expressed p53 died in a small period of time.
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