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Description
Phospho-IRF3 (Ser396) Recombinant Rabbit mAb (S-3598)Product Specification Host Rabbit Antigen Phospho IRF 3 (Ser396) Synonyms Interferon regulatory factor 3; IRF3 Location Nucleus Accession Q14653 Clone Number S 3598 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample HT 29 (transfected with 2. 5 g ml Poly (I: C) for 6 hours) Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%
Product Specification
| Host | Rabbit |
| Antigen | Phospho-IRF-3 (Ser396) |
| Synonyms | Interferon regulatory factor 3; IRF3 |
| Location | Nucleus |
| Accession | Q14653 |
| Clone Number | S-3598 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | HT-29 (transfected with 2.5 μg/ml Poly (I:C) for 6 hours) |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
Phospho-IRF3 (Ser396) refers to the activated form of Interferon Regulatory Factor 3 (IRF-3), a critical transcription factor in the innate immune system, specifically phosphorylated at serine residue 396 within its C-terminal regulatory domain. This post-translational modification is primarily catalyzed by the kinases TBK1 and IKKε following the detection of viral pathogens by pattern recognition receptors such as TLR3, TLR4, or cytosolic sensors like RIG-I and MDA5. Upon phosphorylation at Ser396, IRF-3 undergoes a conformational change that disrupts its autoinhibitory state, promoting homodimerization and subsequent translocation from the cytoplasm into the nucleus. Once inside the nucleus, the phospho-IRF-3 dimer binds to interferon-stimulated response elements (ISREs) in the promoter regions of target genes, driving the robust transcription of type I interferons (particularly IFN-β) and other antiviral cytokines, thereby establishing an essential antiviral state to limit viral replication and spread.
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