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Description
CLECSF6/DCIR/CLEC4A His Tag Protein, HumanProduct Specification Species Human Synonyms CD367 Protein, Human; CLEC4A Protein, Human; CLECSF6 Protein, Human; DCIR Protein, Human; DDB27 Protein, Human; HDCGC13P Protein, Human; LLIR Protein, Human Accession Q9UMR7 Amino Acid Sequence Gln70 Leu237, with N terminal 8*His hhhhhhhhgggsQKYSQLLEKKTTKELVHTTLECVKKNMPVEETAWSCCPKNWKSFSSNCYFISTESASWQDSEKDCARMEAHLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQRHWQWVDQTPYNESSTFWHPREPSDPNERCVVLNFRKSPKRWGWNDVNCLGPQRSVCEMMKIHL
Product Specification
| Species | Human |
| Synonyms | CD367 Protein, Human; CLEC4A Protein, Human; CLECSF6 Protein, Human; DCIR Protein, Human; DDB27 Protein, Human; HDCGC13P Protein, Human; LLIR Protein, Human |
| Accession | Q9UMR7 |
| Amino Acid Sequence | Gln70-Leu237, with N-terminal 8*His hhhhhhhhgggsQKYSQLLEKKTTKELVHTTLECVKKNMPVEETAWSCCPKNWKSFSSNCYFISTESASWQDSEKDCARMEAHLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQRHWQWVDQTPYNESSTFWHPREPSDPNERCVVLNFRKSPKRWGWNDVNCLGPQRSVCEMMKIHL |
| Expression System | HEK293 |
| Molecular Weight | 23-28kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Gene ID: 50856, updated on 7-Sep-2023 |
Background
DCIR, also known as Lectin-like Immunoreceptor (LLIR), is a type II membrane protein belonging to the C-type lectin domain family and is designated CLEC4A. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. DCIR expressed on antigen presenting cells and granulocytes and acts as an inhibitory receptor via an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM). It may also be involved via its ITIM motif in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.
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