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Description
Pex14 Recombinant Rabbit mAb (S-2379-8)Product Specification Host Rabbit Antigen Pex14 Synonyms Peroxisomal membrane protein PEX14; PTS1 receptor docking protein; Peroxin 14; Peroxisomal membrane anchor protein PEX14; PEX14 Immunogen Synthetic Peptide Accession O75381 Clone Number S 2379 8 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample Raji, A431, HeLa, 293T, HepG2 Purification Protein A Concentration 2 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | Pex14 |
| Synonyms | Peroxisomal membrane protein PEX14; PTS1 receptor-docking protein; Peroxin-14; Peroxisomal membrane anchor protein PEX14; PEX14 |
| Immunogen | Synthetic Peptide |
| Accession | O75381 |
| Clone Number | S-2379-8 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | Raji, A431, HeLa, 293T, HepG2 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:100 | Hu |
| ICC | 1:50 | Hu |
Background
PEX14, encoded by the PEX14 gene, is an integral peroxisomal membrane protein whose C-terminus faces the cytosol and constitutes the docking site for the PTS1 receptor PEX5 (and, indirectly, the PTS2 receptor PEX7), thereby nucleating the PEX13-PEX14 translocon pore that imports peroxisomal matrix proteins; beyond its essential role in peroxisome biogenesis, PEX14 also binds microtubules to drive organelle motility, functions as a transcriptional corepressor by recruiting histone deacetylases, and—uniquely among peroxins—is strictly required for selective autophagic degradation of peroxisomes (pexophagy), while mutations in PEX14 produce a Zellweger-syndrome phenotype .
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