SKU: 55198358826

Mouse Anti-Human/Mouse T-Bet Antibody (S-4477)

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Description

Mouse Anti-Human/Mouse T-Bet Antibody (S-4477)Product Specification Host Mouse Antigen T Bet Synonyms T box transcription factor TBX21; T cell specific T box transcription factor T bet; Transcription factor TBLYM; TBET; TBLYM; TBX21 Location Nucleus Accession Q9UL17Q9JKD8 Clone Number S 4477 Antibody Type Mouse mAb Isotype IgG1,k Application ICFCM Reactivity Hu, Ms Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability

Product Specification


Host Mouse
Antigen T-Bet
Synonyms T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM; TBET; TBLYM; TBX21
Location Nucleus
Accession Q9UL17、Q9JKD8
Clone Number S-4477
Antibody Type Mouse mAb
Isotype IgG1,k
Application ICFCM
Reactivity Hu, Ms
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
ICFCM 1:200 Hu, Ms

Background

T-bet (T-box transcription factor TBX21) is a master regulator protein essential for the differentiation and function of T helper 1 (Th1) cells, playing a pivotal role in the adaptive immune response against intracellular pathogens such as viruses and bacteria. Encoded by the TBX21 gene, this nuclear transcription factor binds to specific DNA sequences to activate the expression of hallmark Th1 cytokines, most notably interferon-gamma (IFN-γ), while simultaneously repressing the development of alternative T cell lineages like Th2 and Th17 by inhibiting their respective lineage-defining transcription factors (GATA3 and RORγt). Beyond its critical function in CD4+ T cells, T-bet also governs the maturation and cytotoxic potential of CD8+ T cells and natural killer (NK) cells, thereby orchestrating a robust cell-mediated immunity; however, its dysregulation or overexpression is implicated in various autoimmune disorders and chronic inflammatory conditions, making it a significant target for immunotherapeutic interventions aimed at modulating immune balance.

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SKU: 55198358826

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4.6 ★★★★★
Based on 306 reviews
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Colette
Bozeman, US
★★★★★ 5
Glowing face with sun protection. No fuss, no muss!
Item Package Quantity: 1
Wow, I love this stuff. It does make your skin hydrated and glow with health while protecting it from the sun. No shiny oil, just glow, and best of all, no need to mess up your makeup reapplying sunscreen. You can use it to set your makeup for extra protection (I still use sunscreen under makeup). The mist comes out so fine and even, no drips or glob. The scent is light and fades quickly. The best I've dried out of all the other brands.
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Reviewed in the United States on May 20, 2026
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Verified Purchase
Anne L
Los Angeles, US
★★★★★ 5
Lightweight and glowy
Item Package Quantity: 1
I’ve been using the Naked Sundays SPF 50 Hydrating Sunscreen, and it’s quickly become a staple — especially for long days outside and on the tennis court. The texture is lightweight and smooth, and it blends in beautifully without leaving a white cast or greasy feel. What I love most is the finish: it gives a natural, healthy glow without looking shiny or heavy. It layers really well under makeup and doesn’t pill, even when I’m reapplying throughout the day. I also appreciate how hydrating it feels without clogging pores or causing breakouts. Performance-wise, it holds up well during activity and sweating (which matters for me during matches). The packaging is easy to toss in a tennis bag for quick reapplication. If I had to note one thing, it’s slightly pricier than drugstore options — but the quality and wearability make it worth it. Best for: everyday wear, outdoor sports, and anyone wanting high SPF protection with a comfortable, skin-like finish. Would absolutely repurchase.
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Reviewed in the United States on March 17, 2026
M
Verified Purchase
martha ramirez
Cuba, US
★★★★★ 1
Stings! Waste of money! Doesn’t accept returns!
Item Package Quantity: 1
Very disappointed with this spray sunscreen. Although I’m usually not sensitive to sunscreens or face creams in general, this product made my eyes burn and tear up so much and so fast that I’m not able to use it. Such a waste. I even tried applying while covering just my eyes to avoid that area and it still stings. And it also goes on greasy, definitely not cute glowy looking. It is not a flattering shine. For the price I’m very disappointed and even upset that I didn’t notice before buying that you cannot return it. Don’t waste your money.
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Reviewed in the United States on June 6, 2026
J
Verified Purchase
Jen Reviews
Omaha, US
★★★★★ 5
☀️ Holy Grail SPF Mist! especially for makeup days 💦
Item Package Quantity: 1, Item Package Quantity: 1
If you hate the feeling of greasy sunscreen but still want serious protection, this is the glow-up you’ve been waiting for. I use this as the last step in my morning skincare and as a top-up over makeup throughout the day. It’s lightweight, non-greasy, and gives a dewy finish without looking oily, just a fresh, hydrated glow ✨ The mist is fine and even (no big droplets or weird stickiness), and it dries down fast. No white cast, no clogged pores, no breakouts. Just SPF 50+ that actually works with your makeup instead of wrecking it. I’ve even used it midday at Disneyland and didn’t burn once, and I’m someone who burns if I think too hard about sunshine 🥵 Helpful hint: Shake it well before spraying, and hold it about 6 inches from your face for a nice even mist. One pass usually does the trick, but I like to go back over my nose and cheeks for extra protection ☁️ It also doubles as a midday makeup refresher, especially when your foundation starts looking a little dry 🧴 I brought this with me on a full weekend trip to Disneyland and it absolutely earned its spot in my park bag 🎒 I was in the sun all day, both days, and didn’t burn at all, even with minimal shade and back-to-back rides 🎢 It layered like a dream over makeup, didn’t feel heavy, and made touch-ups fast and easy in between churros. This mist officially passed the Disneyland test. 🎡☀️💕
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Reviewed in the United States on September 19, 2025
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Verified Purchase
I.F.
Houston, US
★★★★★ 3
Good but heavy smell
Item Package Quantity: 1
I will keep using this bc it works and the sprayer is sooo nice but the smell is so overwhelming. It’s not a bad smell but it’s just so heavy. I’ll use this one but I don’t see myself repurchasing.
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Reviewed in the United States on May 4, 2026

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