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Description
Alexa Fluor 647-Labeled CDH17/LI-cadherin His Tag Protein, HumanProduct Specification Species Human Synonyms Liver intestine cadherin,HPT 1,CDH16,Intestinal peptide associated transporter HPT 1,LI cadherin,HPT 1 Cadherin,Cadherin 17,LI Cadherin (Liver Intestine),HPT1,Human Intestinal Peptide Associated Transporter HPT 1,LI Cadherin,Cadherin,Cadherin 17,Human Peptide Transporter 1,Cadherin 16 Accession Q12864 Amino Acid Sequence Gln23 Met787 with His Tag at C Terminus Expression System HEK293 Molecular Weight 95
Product Specification
| Species | Human |
| Synonyms | Liver-intestine cadherin,HPT-1,CDH16,Intestinal peptide-associated transporter HPT-1,LI-cadherin,HPT-1 Cadherin,Cadherin 17,LI Cadherin (Liver-Intestine),HPT1,Human Intestinal Peptide-Associated Transporter HPT-1,LI Cadherin,Cadherin,Cadherin 17,Human Peptide Transporter 1,Cadherin-16 |
| Accession | Q12864 |
| Amino Acid Sequence | Gln23-Met787 with His Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 95-110kDa (Reducing) |
| Conjugation | Alexa Fluor® 647 |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH7.4 |
| Stability & Storage | · 12 months from date of receipt stored at -20 to -80℃. |
| Reference | 1. Liu LX, et al. (2009) Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology. 50(5): 1453-63. |
Background
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. It's also involved in intestinal peptide transport.
Guidelines
Following recommended dosage for experiments strictly. If the population clustering is not distinct, the recommended dosage could be appropriately increased by 2–5 folds.
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