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Description
TLR4 Recombinant Mouse mAb (S-3033)Product Specification Host Mouse Antigen TLR4 Synonyms Toll like receptor 4; hToll; CD284 Location Endosome, Cell membrane Accession O00206 Clone Number S 3033 Antibody Type Mouse mAb Isotype IgG2b Application WB Reactivity Ms Positive Sample RAW264. 7, J774A. 1, A20 Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12
Product Specification
| Host | Mouse |
| Antigen | TLR4 |
| Synonyms | Toll-like receptor 4; hToll; CD284 |
| Location | Endosome, Cell membrane |
| Accession | O00206 |
| Clone Number | S-3033 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b |
| Application | WB |
| Reactivity | Ms |
| Positive Sample | RAW264.7, J774A.1, A20 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
Background
Toll-like receptor 4 (TLR4) is a 839-amino-acid type I transmembrane pattern-recognition receptor expressed predominantly on myeloid and epithelial cells that, through cooperation with the accessory proteins MD-2 and CD14, recognizes bacterial lipopolysaccharide and numerous endogenous danger-associated molecules, triggering MyD88- and TRIF-dependent signaling cascades that culminate in rapid activation of NF-κB, MAP kinases, and interferon regulatory factors, thereby inducing robust pro-inflammatory cytokine, chemokine, and type I interferon responses essential for innate immunity and for bridging adaptive immunity, yet excessive or dysregulated TLR4 activation drives sepsis, atherosclerosis, neurodegeneration, and metabolic syndrome, making this receptor a pivotal therapeutic target modulated by lipid A analogues, small-molecule inhibitors, and biologics under active clinical development.
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