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Description
GPX4 Flag&His tag Protein, HumanProduct Specification Species Human Synonyms GluA4,GLUR4,GLUR4C,GLURD,GPx 4,GSHPx 4,MCSP,NEDSGA,PHGPx Accession P36969 1 Amino Acid Sequence Gly26 Phe197 with Flag Tag at the N Terminus, and His Tag at the C Terminus Expression System HEK293 Molecular Weight 20 25kDa (Reducing) Purity 95% by SDS PAGE & > 85% SEC HPLC Conjugation Unconjugated Tag His Tag, Flag Tag Physical Appearance Lyophilized powder Storage Buffer 20mM Tris, 150mM NaCl, PH7. 4, 5%
Product Specification
| Species | Human |
| Synonyms | GluA4,GLUR4,GLUR4C,GLURD,GPx-4,GSHPx-4,MCSP,NEDSGA,PHGPx |
| Accession | P36969-1 |
| Amino Acid Sequence | Gly26-Phe197 with Flag Tag at the N-Terminus, and His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 20-25kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 85% SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag, Flag Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 20mM Tris, 150mM NaCl, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Sutherland M, Shankaranarayanan P, Schewe T, Nigam S. Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism. Biochem J. 2001 Jan 1;353(Pt 1):91-100. |
Background
GPX4 (Glutathione Peroxidase 4) is a pivotal antioxidant enzyme, unique for its active site containing the rare amino acid selenocysteine, which is essential for its function. It directly reduces a broad spectrum of phospholipid hydroperoxides within cell membranes, thereby maintaining membrane integrity and playing a central role in inhibiting ferroptosis—a form of iron-dependent, non-apoptotic cell death. Its functions are critical for sperm development, T-cell immunity, and neuronal survival. Clinically, GPX4 is a key therapeutic target, as its dysfunction is implicated in conditions ranging from male infertility and neurodegenerative diseases to epilepsy and cancer, with modulating its activity being a promising strategy for treating ferroptosis-related pathologies.
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