SKU: 83017184523

IL-23 R Fc Chimera Protein, Human

$110.25 $122.50
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Description

IL-23 R Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IBD17,IL 23 receptor Accession Q5VWK5 1 Amino Acid Sequence Gly24 Gly355 with hIgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 90 110kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms IBD17,IL-23 receptor
Accession Q5VWK5-1
Amino Acid Sequence

Gly24-Gly355 with hIgG1 Fc at the C-Terminus
Expression System HEK293
Molecular Weight

90-110kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Benson JM, Sachs CW, Treacy G, Zhou H, Pendley CE, Brodmerkel CM, Shankar G, Mascelli MA. Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab. Nat Biotechnol. 2011 Jul;29(7):615-24.
2.Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, Powrie F, Maloy KJ. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med. 2006 Oct 30;203(11):2473-83.

Background

Interleukin-23 (IL-23) is a heterodimeric cytokine composed of p19 and p40 subunits. Its functional receptor, IL-23R, combines with the IL-12Rβ1 subunit to form a type I cytokine receptor complex. This complex activates the downstream JAK2-STAT3 signaling pathway, regulating the proliferation, differentiation, and secretion of inflammatory factors in immune cells such as T cells and NK cells. It plays a central role in sustaining Th17 cell-mediated inflammatory responses. Clinically, abnormal activation of the IL-23/IL-23R pathway is a key pathogenic mechanism in autoimmune diseases such as psoriasis and inflammatory bowel disease. Additionally, it promotes tumorigenesis within the tumor microenvironment, making it a critical therapeutic target.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
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  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 83017184523

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4.7 ★★★★★
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All in one heavy duty charging brick
Love that this charger has a metal housing — it feels heavy-duty and well-built in a way most charging bricks don’t. Charges fast, handles a laptop, a phone, and a tablet at the same time without breaking a sweat, and the foldable prongs make it actually travel-friendly. 65W is the sweet spot for daily life: enough to power a MacBook Air or Pro, plus charge two more devices. Pros: • Solid metal build feels premium • 65W is plenty for laptops, tablets, and phones • Three ports (2 USB-C, 1 USB-A) • Foldable prongs for travel • Compact for the wattage Cons: • Heavier than plastic chargers (the trade-off for the build) • Maxing out all three ports splits the wattage, so not everything fast-charges simultaneously Tips: • Use a high-quality USB-C cable to actually hit fast charging speeds • For laptop charging, plug into the top USB-C port for max output • Great single-charger replacement for travel — covers laptop, phone, and tablet in one brick
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Reviewed in the United States on May 31, 2026
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Anonymous
Boise, US
★★★★★ 5
100% would recommend, FAST and PORTABLE
The Anker 65W 3-Port Fast Compact Foldable USB-C Charger is a really nice charger overall. It has foldable prongs and 3 different ports, which makes it super useful for charging multiple devices at once, especially for college students or travel setups. It’s also really portable and easy to throw into a backpack but hefty in quality. The charging speed is excellent too. I can charge my MacBook from around 30% to 65% in about an hour. It does get a little warm while charging, but it cools down well and has never been an issue for me.
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Reviewed in the United States on May 9, 2026
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Ray
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Compact, lots of power, great for travel.
I tested it at full power. It does what its advertised to do. At full power it does get fairly warm, not near warm enough to be a hazard. It can't be covered up, It may overheat if it's covered with stuff. I got it for travel. It will charge my computer, tablet and phone just fine. It shares the 65W, so charging of each device may slow as you plug in more devices
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Reviewed in the United States on May 30, 2026
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Sticks out a lot.
Nice and reliable no problems so far. but does stick out the wall more than other models.
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