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Description
USAG1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CDA019; cystine knot containing secreted protein; DKFZp564D206; Ectodermal BMP inhibitor; Ectodin; sclerostin domain containing 1; sclerostin domain containing protein 1; SOSTDC1; USAG1; USAG 1; USAG1uterine sensitization associated protein 1; Uterine sensitization associated gene 1 protein; WISE Accession Q6X4U4 Amino Acid Sequence Phe24 Ser206, with C terminal hIgG1 Fc Expression System HEK293 Molecular
Product Specification
| Species | Human |
| Synonyms | CDA019; cystine-knot containing secreted protein; DKFZp564D206; Ectodermal BMP inhibitor; Ectodin; sclerostin domain containing 1; sclerostin domain-containing protein 1; SOSTDC1; USAG1; USAG-1; USAG1uterine sensitization-associated protein-1; Uterine sensitization-associated gene 1 protein; WISE |
| Accession | Q6X4U4 |
| Amino Acid Sequence | Phe24-Ser206, with C-terminal hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 50-70kDa (Reducing) |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Laurikkala, J. et al. (2003) Dev. Biol. 264:91. 2.Yanagita, M. et al. (2004) Biochem. Biophys. Res. Commun. 316:490. 3.Lintern, K.B. et al. (2009) J. Biol. Chem. 284:23159. |
Background
USAG1 (uterine sensitization‑associated gene 1), also called WISE (Wnt modulator in surface ectoderm) or Ectodin, gene name SOSTDC1, is a secreted, monomeric 26 ‑ 32 kDa glycoprotein of the sclerostin family of BMP antagonists. USAG1 is proposed to coordinate BMP, Wnt, FGF and SHH signals that regulate apoptosis during tooth development. Deletion of USAG1 results in mice with supernumerary teeth, while concurrent decreased expression of LRP5 and LRP6 restores normal tooth configurations. USAG1-/- mice show decreased susceptibility to kidney injury which is reversed by administration of a neutralizing antibody to BMP7. In a mouse model of Alport syndrome, deletion of USAG1 alternates disease progression. These results support a proposed USAG1/WISE antagonism of BMP and Wnt signaling pathways in kidney and tooth development. USAG1 expression by uterine luminal epithelium is also associated with the timing and positioning of blastocyst implantation.
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