SKU: 12965923569

Human CD44, His tag

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Description

Human CD44, His tagProduct Specification Species Human Synonyms CDw44, Epican, Extracellular matrix receptor III (ECMR III), GP90 lymphocyte homing adhesion receptor, HUTCH I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1 (PGP 1), Phagocytic glycoprotein I (PGP I), LHR, MDU2, MDU3, MIC4 Accession P16070 Amino Acid Sequence Protein sequence (P16070, Gly32 Thr232, with C 10*His)

Product Specification


Species Human
Synonyms CDw44, Epican, Extracellular matrix receptor III (ECMR-III), GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1 (PGP-1), Phagocytic glycoprotein I (PGP-I), LHR, MDU2, MDU3, MIC4
Accession P16070
Amino Acid Sequence

Protein sequence (P16070, Gly32-Thr232, with C-10*His) GVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATGGGGSHHHHHHHHHH

Expression System HEK293
Molecular Weight Predicted MW: 23.6 kDa Observed MW: 34-70 kDa
Purity >95% by SDS-PAGE
Endotoxin <1EU/μg
Tag with C-10*His
Physical Appearance Lyophilized Powder
Storage Buffer Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

Background

The CD44 antigen is a cell-surface glycoprotein involved in cell proliferation, cell differentiation, cell migration, angiogenesis, presentation of cytokines, chemokines, and growth factors to the corresponding receptors, and docking of proteases at the cell membrane, as well as in signaling for cell survival. CD44 is a receptor for hyaluronic acid and internalizes metals bound to hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44, along with CD25, is used to track early T cell development in the thymus. CD44 expression is an indicative marker for effector-memory T-cells. In addition, variations in CD44 are reported as cell surface markers for some breast and prostate cancer stem cells. Endometrial cells in women with endometriosis demonstrate increased expression of splice variants of CD44, and increased adherence to peritoneal cells. CD44 variant isoforms are also relevant to the progression of head and neck squamous cell carcinoma. High levels of the adhesion molecule CD44 on leukemic cells are essential to generate leukemia.

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Exchange/Return Notes
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SKU: 12965923569

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Chrystal
Houston, US
★★★★★ 4
Cute
Size: 6.5, Color: Black (Pu)
Cute, comfortable.
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Reviewed in the United States on April 14, 2026
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SparkaliSB
Cuba, US
★★★★★ 5
Trying to get what's in picture
Size: 9, Color: Natural Nbpu
Amazon said my size was a 10. So i ordered a 10. Waaaay too long, wide big in general, and I have a wide foot so I was pleasantly surprised. Company did not offer any color in size 9.5 but according to their size guide I "might" fit into a 9! Again, pleasantly surprised that i totally did and even when I put in my "Dr. Scholl's" inserts, i have slight wiggle room for when feet swell. Overall I am happy with the shoe fit, comfortability and height...not that I'd wear these for more than 8 hrs., but comfy enough for a wedding or to wear to work when I have a "mostly office day" instead of out in the yard. HOWEVER... i loved the color and suede-ey look/feel pattern of the size 10. It was exactly as picture/info described. But I'm not sure what happened to the size 9? wth? Although i ORDERED exact same shoe/color but in smaller size...what I got was a much lighter color, and NOT the suede fabric...more nubuck. Bu inside of shoe had same info/tag as the 10. Really hoping that it was a packing/labeling error. Will try one more time to order the 9, in the same 'name' fabric. Fingers crossed that I get what I ordered/want. Otherwise it'll be a return and less stars.
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Reviewed in the United States on November 4, 2024
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donald j.
Charlottesville, US
★★★★★ 5
I can’t say anything but I really love them
Size: 6, Color: Natural Nbpu
They look great. They feel great
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Reviewed in the United States on April 10, 2026
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Babiche Design
Chelsea, US
★★★★★ 3
stiff like cardboard tops of shoes
Size: 5.5, Color: Natural Nbpu
These shoes are good enough quality and cute cute - even fit great, EXCEPT the faux leather top (part that encircles your leg) is so stiff, that when you walk, it cuts into your leg like hard cardboard making it difficult to walk comfortably. I do like them otherwise, but can't stand the hard, unbending top of these shoes.
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Reviewed in the United States on January 15, 2025
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Pamela
Cuba, US
★★★★★ 5
Great for wide feet
Size: 9, Color: Black Nubuck
Beautiful- great for wide feet, camouflage slight swelling in feet / ankles beautifully. Look great with everything; adds a touch of elegance & rock star. Super fast shipping too!
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Reviewed in the United States on November 8, 2025

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