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Description
APRIL/TNFSF13 Protein, HumanProduct Specification Species Human Synonyms Tumor necrosis factor ligand superfamily member 13, A proliferation inducing ligand (APRIL), TNF and APOL related leukocyte expressed ligand 2 (TALL 2), TNF related death ligand 1 (TRDL 1), CD256 Accession O75888 Amino Acid Sequence Gln111 Leu250 Expression System HEK293 Molecular Weight 18 20 kDa (Reducing) Purity >95% by SDS PAGE; >90% by HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag
Product Specification
| Species | Human |
| Synonyms | Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand (APRIL), TNF- and APOL-related leukocyte expressed ligand 2 (TALL-2), TNF-related death ligand 1 (TRDL-1), CD256 |
| Accession | O75888 |
| Amino Acid Sequence | Gln111-Leu250 |
| Expression System | HEK293 |
| Molecular Weight | 18-20 kDa (Reducing) |
| Purity | >95% by SDS-PAGE; >90% by HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 20mM Tris, 300mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Nature. 2021 Sep;597(7874):92-96. |
Background
APRIL (A Proliferation-Inducing Ligand), also known as TNFSF13, is a member of the tumor necrosis factor (TNF) superfamily encoded by the TNFSF13 gene located on human chromosome 17p13. This 250-amino acid type II transmembrane protein functions as a homotrimeric cytokine and plays pivotal roles in immune regulation, B cell biology, and various pathological conditions including cancer, autoimmune diseases, and cardiovascular disorders.
APRIL is extensively studied in systemic lupus erythematosus (SLE), Sjögren's syndrome, IgA nephropathy, and rheumatoid arthritis. Elevated APRIL levels correlate with disease activity, making it a therapeutic target. Atacicept (TACI-Ig fusion protein) neutralizes both APRIL and BAFF, showing promise in clinical trials.
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