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Description
IL-13 Protein, RatProduct Specification Species Rat Synonyms Interleukin 13, IL 13, T cell activation protein P600 Accession P42203 Amino Acid Sequence Thr19 His131 Expression System E. coli Molecular Weight 11 12 kDa (Reducing) Purity >95% by SDS PAGE; >90% by HPLC; Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure
Product Specification
| Species | Rat |
| Synonyms | Interleukin-13, IL-13, T-cell activation protein P600 |
| Accession | P42203 |
| Amino Acid Sequence | Thr19-His131 |
| Expression System | E.coli |
| Molecular Weight | 11-12 kDa (Reducing) |
| Purity | >95% by SDS-PAGE; >90% by HPLC; |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Nature. 1993 Mar 18;362(6417):248-50. |
Background
Rat IL-13 is a 12.3 kDa, non-glycosylated monomeric cytokine consisting of 113 amino acids (Uniprot ID: P42203) with a bundled four α-helix configuration stabilized by two internal disulfide bonds. The mature protein shares 75% amino acid sequence identity with mouse IL-13, 59% with human, and 60% with rhesus monkey orthologs, reflecting strong functional conservation across species.
IL-13 is primarily secreted by T helper type 2 (Th2) cells but is also produced by various immune and non-immune cell types including mast cells, eosinophils, basophils, NK cells, and epithelial cell. In rats, IL-13 expression is dynamically regulated during immune challenges, with elevated levels detected in bronchoalveolar lavage (BAL) cells following allergen stimulation.
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