SKU: 77152377152

IL-23 R Fc Chimera Protein, Human

$110.25 $122.50
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Description

IL-23 R Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IBD17,IL 23 receptor Accession Q5VWK5 1 Amino Acid Sequence Gly24 Gly355 with hIgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 90 110kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms IBD17,IL-23 receptor
Accession Q5VWK5-1
Amino Acid Sequence

Gly24-Gly355 with hIgG1 Fc at the C-Terminus
Expression System HEK293
Molecular Weight

90-110kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Benson JM, Sachs CW, Treacy G, Zhou H, Pendley CE, Brodmerkel CM, Shankar G, Mascelli MA. Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab. Nat Biotechnol. 2011 Jul;29(7):615-24.
2.Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, Powrie F, Maloy KJ. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med. 2006 Oct 30;203(11):2473-83.

Background

Interleukin-23 (IL-23) is a heterodimeric cytokine composed of p19 and p40 subunits. Its functional receptor, IL-23R, combines with the IL-12Rβ1 subunit to form a type I cytokine receptor complex. This complex activates the downstream JAK2-STAT3 signaling pathway, regulating the proliferation, differentiation, and secretion of inflammatory factors in immune cells such as T cells and NK cells. It plays a central role in sustaining Th17 cell-mediated inflammatory responses. Clinically, abnormal activation of the IL-23/IL-23R pathway is a key pathogenic mechanism in autoimmune diseases such as psoriasis and inflammatory bowel disease. Additionally, it promotes tumorigenesis within the tumor microenvironment, making it a critical therapeutic target.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
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  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 77152377152

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Madisontutu
Grantham, US
★★★★★ 5
great for our blind dog
Size: Large 3"
our pup is a blind but active senior and these balls have a bell inside so she can continue playing ball! this is the second time i have ordered these.. love um!
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Reviewed in the United States on May 31, 2026
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L B
New York, US
★★★★★ 5
Great toys for dogs or cats
Size: Small 2"
Sturdy, durable toys. My dog loves the jingle. Great size. Fits in her mouth but not so small we have to worry about her swallowing them.
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Reviewed in the United States on February 28, 2026
A
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Amazon Customer
Bozeman, US
★★★★★ 5
Perfect for your blind babies
Size: Large 3", Size: Large 3"
I know most dogs that go blind in their later years do just fine, but when they were very active with a daily ball fetch routine, it can be tough to watch. These little balls are exactly what I needed!! The jingle ball inside is great and as long as you've got plenty of obstacle free space, it's just like playing ball when he had his sight. He also loves to just carry it around and chew on it. Highly recommend
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Reviewed in the United States on May 9, 2026
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MARIA LAO
Grantham, US
★★★★★ 5
Hydration
Size: 0.99 FL Oz (Pack of 17)
Excellent lotion makes and looks great especially dry skin
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Reviewed in the United States on June 9, 2021
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Desda C. Kerr
Houston, US
★★★★★ 5
Excellent lotion. Its keeps your hand moist for hours ...
Size: 0.99 FL Oz (Pack of 17)
Excellent lotion. Its keeps your hand moist for hours - all dryness is gone. It is not too greasy. An excellent lotion
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Reviewed in the United States on February 3, 2018

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