SKU: 80231058652

Alexa Fluor 647-Labeled ICAM-1/CD54 Fc Chimera Protein, Human

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Description

Alexa Fluor 647-Labeled ICAM-1/CD54 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms BB2,CD54 antigen,CD54,cell surface glycoprotein P3. 58,human rhinovirus receptor,ICAM1,ICAM 1,intercellular adhesion molecule 1 (CD54) Accession P05362 1 Amino Acid Sequence Gln28 Glu480 with hIgG1 Fc Tag at C Terminus Expression System HEK293 Molecular Weight 49 72kDa (Reducing) Conjugation Alexa Fluor 647 Tag Human IgG1 Fc Physical Appearance Liquid Storage Buffer PBS, pH7. 4 Stability & Storage 12 months

Product Specification


Species Human
Synonyms BB2,CD54 antigen,CD54,cell surface glycoprotein P3.58,human rhinovirus receptor,ICAM1,ICAM-1,intercellular adhesion molecule 1 (CD54)
Accession P05362-1
Amino Acid Sequence

Gln28-Glu480 with hIgG1 Fc Tag at C-Terminus
Expression System HEK293
Molecular Weight

49-72kDa (Reducing)
Conjugation Alexa Fluor® 647
Tag Human IgG1 Fc
Physical Appearance Liquid
Storage Buffer

PBS, pH7.4
Stability & Storage

· 12 months from date of receipt stored at -20 to -80℃.
· 1 week, 2 to 8℃ under sterile conditions
· Recommend to aliquot the protein into smaller quantities for optimal storage.
· Please avoid repeated freeze-thaw cycles.
Reference

1、Gu H F. et al. (2013) Association of intercellular adhesion molecule 1 (ICAM1) with diabetes and diabetic nephropathy. Front Endocrinol. 3: 179.
2、 Williams M R. et al. (2013) ICAM1 ligation‐induced transmigratory complex formation regulates leukocyte transendothelial migration. FASEB J. 27(S1): 57.5-57.5.

Background

ICAM-1 is a cell surface glycoprotein expressed at a low basal level in immune, endothelial (EC) and epithelial cells, but is up-regulated in response to inflammatory stimulation. The function of ICAM-1 has been best studied in leukocyte transendothelial migration (TEM), where ICAM-1 regulates leukocyte rolling and adhesive interactions with the vessel wall, and guides leukocyte crossing of the endothelial layer. More recently, functional studies identified several new roles of ICAM-1 in epithelial injury-resolution responses, innate and adaptive immune responses in inflammation, and tumorigenesis.

Guidelines

Following recommended dosage for experiments strictly. If the population clustering is not distinct, the recommended dosage could be appropriately increased by 2–5 folds.

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SKU: 80231058652

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4.1 ★★★★★
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C
Verified Purchase
Carmen Alicea
Pawtucket, US
★★★★★ 5
A Beta Worth Rooting For
Format: Kindle
In Spare, Violet Fox flips the omegaverse on its head, giving us a Beta heroine determined to make her mark. Joining the Beta Trials to support her sick father, she's thrown into a pack that doesn't want her, especially the possessive Alphas. But here's the twist: their sweet Omega turns out to be her scent match. Cue the angst, forbidden tension, and a slow-burn romance that will make your heart ache in the best way. Violet Fox delivers an emotional, refreshing take on the genre, proving Betas aren't "spares." They're stars.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 10, 2025
C
Verified Purchase
C. Hunter
Port Orchard, US
★★★★★ 5
Beta, Alpha, Omega oh my!
Format: Kindle
Omegas are precious and given to Alphas & their packs... but the Betas want in too. To this end, the Beta government is rolling out its trial of assigning a Beta to each Alpha-Omega pack. But forcing a Beta into a pack where they are not wanted will not end well... Of course, no one expected the Omega to fall for the assigned Beta. Great read and cliffhanger
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 15, 2025
B
Verified Purchase
B. Stubby
Belleville, US
★★★★★ 3
A familiar story, just with…..less.
Format: Kindle
So, as other reviewers make clear, this is very similar to Pack Darling and The Beta. It’s much closer aligned with The Beta, in plot and maybe more like Pack Darling with characters. That being said, I don’t hate this…..but it wasn’t great either. It’s both books mentioned but just….less. Less angst, less emotion, less feeling. The plot feels very half fleshed out, and the “bad guy” feels underwhelming. I didn’t really feel any real emotions from and of the male leads, except maybe Oliver. The others fell sorta flat for me. And Mika makes herself out to be this big bad ass straight outta training and then we never see it from here again with the one fitting room incident as the exception. SPOILER: The whole, “Oh, I’m actually probably an Omega, but I don’t wanna be but I do actually wanna be but no one can ever know my secret that I do nothing to hide “ thing fell so flat. She never commutes to believing she was secretly an omega, but also mentions her “secret” a lot. It just felt so manufactured. I’m intrigued enough to read part 2 and see how the author closes everything out, but this is not one I’ll recommend or ever come back to.
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Reviewed in the United States on February 13, 2024
S
Verified Purchase
SR
Draper, US
★★★★★ 5
Good start to a series
Format: Kindle
I delayed reading the series for reasons I don’t remember. But my TBR list is huge so I thought I’d take a shot of this and I was pleasantly surprised. I didn’t think the blurb about it was anything special. But it was a very good book. It took some interesting twists and turns. I am so glad the second book is already out. Because I would not have waited patiently. Very slow burn but good storyline. 🔥🔥/5
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Reviewed in the United States on January 3, 2025
J
Verified Purchase
Jammie Clark
Charlottesville, US
★★★★★ 4
A good read
Format: Kindle
Multiple points of view. 3 Alpha men and an Omega male. She is a Beta in training for a new program placing betas in Alpha/Omega packs. Mila is only doing the program for the money to take care of her dad. She wasn't expecting to fall for a pack but when she sees this packs Omega she is done for. There is just something about him. His Alphas are good looking as well. Too bad she is hiding a secret and their government is acting shady. I liked it and can't wait to see where their story goes.
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Reviewed in the United States on November 14, 2023

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