SKU: 81041593914

Alexa Fluor 647-Labeled CD20 Flag&His Tag Full Length Protein, Human (Detergent)

Name: Alexa Fluor 647-Labeled CD20 Flag&His Tag Full Length Protein, Human (Detergent)
Brand: bieltoni.com
SKU: 81041593914
Price: 350.00 USD
Availability: InStock
Rating: 4.5382 (877 reviews)

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Description

Alexa Fluor 647-Labeled CD20 Flag&His Tag Full Length Protein, Human (Detergent)Product Specification Species Human Synonyms B lymphocyte surface antigen B1MS4A1B lymphocyte antigen CD20Membrane Spanning 4 Domains A1Leukocyte Surface Antigen Leu 16CD20 AntigenCD20Bp35Membrane Spanning 4 Domains Subfamily A Member 1CD20 ReceptorLEU 16CVID5MS4A2B1S7Antigens CD20Membrane Spanning 4 Domains Subfamily A Member 1B Lymphocyte Cell Surface Antigen B1 Accession P11836 Amino Acid Sequence Full length, with Flag tag at N Terminus, and His

Product Specification

Species	Human
Synonyms	B-lymphocyte surface antigen B1，MS4A1，B-lymphocyte antigen CD20，Membrane Spanning 4-Domains A1，Leukocyte Surface Antigen Leu-16，CD20 Antigen，CD20，Bp35，Membrane-Spanning 4-Domains Subfamily A Member 1，CD20 Receptor，LEU-16，CVID5，MS4A2，B1，S7，Antigens， CD20，Membrane-Spanning 4-Domains， Subfamily A， Member 1，B-Lymphocyte Cell-Surface Antigen B1
Accession	P11836
Amino Acid Sequence	Full length, with Flag tag at N-Terminus, and His tag at C-Terminus
Expression System	HEK293
Molecular Weight	35.4 kDa
Conjugation	Alexa Fluor® 647
Tag	His Tag, Flag Tag
Physical Appearance	Liquid
Storage Buffer	25mM Hepes,150mM NaCl,0.02%DDM
Stability & Storage	· 16 months from date of receipt stored at -80℃. · 1 week,2 to 8℃ under sterile conditions. · Recommend to aliquot the protein into smaller quantities for optimal storage. · Please avoid repeated freeze-thaw cycles.
Reference	1. Rougé L, Chiang N, Steffek M, et al. Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab[J]. Science, 2020, 367(6483): 1224-1230.

Background

CD20 is a 33-37 kDa non-glycosylated protein present on the surface of normal and malignant B lymphocytes and is a member of the MS4A (membrane-spanning 4-domain family A) protein family. The CD20 protein comprises four hydrophobic transmembrane domains, one intracellular domain, and two extracellular domains (a large loop and a small loop), with both the N- and C-termini located within the cytosol. CD20 is associated with several key molecules, including the major histocompatibility complex class II (MHCII), CD40 molecule, B-cell receptor (BCR), and the C-terminal src kinase-binding protein (CBP). CBP interacts with Src kinases such as LYN, FYN, and LCK.A deficiency in CD20 has been shown to result in a reduced number of circulating memory B cells, decreased isotype switching of immunoglobulins (Ig), and lower IgG antibody levels. It is also linked to various pathophysiological diseases and disorders.CD20 plays a crucial role in multiple physiological processes and is thus a promising therapeutic target. The CD20 protein product has the potential to enhance drug discovery efforts in related fields.

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