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Description
Osteoprotegerin/TNFRSF11B His Tag Protein, HumanProduct Specification Species Human Synonyms OCIF,OPG Accession O00300 Amino Acid Sequence Glu22 Leu401 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 50 60kDa (Reducing) Purity 95% by SDS PAGE Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.
Product Specification
| Species | Human |
| Synonyms | OCIF,OPG |
| Accession | O00300 |
| Amino Acid Sequence | Glu22-Leu401 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 50-60kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Shin SY, Kang IS, Kim C. ERK inhibits osteoclast differentiation in RAW 264.7 cells through the osteoprotegerin-mediated autophagy. Bone. 2025 Apr;193:117424. |
Background
Osteoprotegerin (OPG/TNFRSF11B/OCIF) is a member of the tumor necrosis factor receptor superfamily, secreted by osteoblasts as a homodimeric protein.Its core function is as a decoy receptor: 1) By binding with high affinity to RANKL, it competitively blocks RANKL from activating its functional receptor RANK, thereby strongly inhibiting osteoclast differentiation and activation while promoting their apoptosis, making it a key negative regulator of bone resorption. 2) It can also bind to TRAIL (TNFSF10), exerting an anti-apoptotic effect.Bone homeostasis directly depends on the local RANKL/OPG concentration ratio.As a central molecule in maintaining bone metabolic balance, abnormalities in its mechanism are closely associated with osteoporosis. Furthermore, studies suggest it plays important roles in regulating lymph node development and preventing vascular calcification, while its interaction with TRAIL may have implications in oncology and other fields.
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