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Description
IL-1 beta Recombinant Rabbit mAb (S-3173)Product Specification Host Rabbit Antigen IL 1 beta Synonyms Interleukin 1 beta; Catabolin; IL1F2; IL1B Location Cytoplasm, Secreted, Lysosome Accession P01584 Clone Number S 3173 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | IL-1 beta |
| Synonyms | Interleukin-1 beta; Catabolin; IL1F2; IL1B |
| Location | Cytoplasm, Secreted, Lysosome |
| Accession | P01584 |
| Clone Number | S-3173 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Ms |
| ICC | 1:100 | Hu |
Background
Interleukin-1 beta (IL-1β) is a pro-inflammatory cytokine that plays a crucial role in the immune response. It is produced by various cell types, including macrophages and monocytes, in response to infections or tissue injury. IL-1β helps to initiate and amplify the inflammatory response by promoting the expression of other inflammatory mediators and recruiting immune cells to the site of infection or damage. It also has effects on a wide range of physiological processes, such as fever induction, modulation of the hypothalamic-pituitary-adrenal axis, and regulation of metabolism. Dysregulation of IL-1β has been implicated in numerous chronic inflammatory diseases, like rheumatoid arthritis and inflammatory bowel disease, making it an important target for therapeutic interventions.
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