SKU: 80419342

IL-21 R His Tag Protein, Human

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Description

IL-21 R His Tag Protein, HumanProduct Specification Species Human Synonyms IL21R, CD360, NILR Accession Q9HBE5 1 Amino Acid Sequence Cys20 Pro236 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 35 50kDa (Reducing) Purity 95% by SDS PAGE & > 95% SEC HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms IL21R, CD360, NILR
Accession Q9HBE5-1
Amino Acid Sequence

Cys20-Pro236 with His Tag at the C-Terminus

Expression System HEK293
Molecular Weight

35-50kDa (Reducing)

Purity >95% by SDS-PAGE & > 95% SEC-HPLC
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose

Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

Reference

1.Andersen KG, Shylakhter I, Tabrizi S, Grossman SR, Happi CT, Sabeti PC. Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever. Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19;367(1590):868-77.
2.Collins M, Whitters MJ, Young DA. IL-21 and IL-21 receptor: a new cytokine pathway modulates innate and adaptive immunity. Immunol Res. 2003;28(2):131-40.

Background

IL-21 receptor (IL-21R/CD360/NILR) belongs to the type I cytokine receptor family, subfamily 4. It is a single-pass transmembrane protein composed of two fibronectin type-III domains, a WSXWS folding motif and a Box1 JAK-binding motif, and together with the common γ-chain it forms the high-affinity IL-21 receptor complex. Selectively enriched in thymus and spleen, IL-21R is broadly expressed on T, B and NK cells and, via the JAK-STAT pathway, transduces IL-21 signals that drive proliferation, differentiation and memory formation, thereby bridging innate and adaptive immunity. Clinically, hyper-activation of the IL-21/IL-21R axis promotes autoantibody production and is implicated in multiple autoimmune diseases, making this pathway a key biomarker and therapeutic target for autoantibody-mediated disorders.

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SKU: 80419342

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