SKU: 96004785978

CDCP1 His Tag Protein, Human

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Description

CDCP1 His Tag Protein, HumanProduct Specification Species Human Synonyms CD318, TRASK, UNQ2486, Membrane glycoprotein gp140 Accession Q9H5V8 1 Amino Acid Sequence Phe30 Thr667 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 100 120kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size

Product Specification


Species Human
Synonyms CD318, TRASK, UNQ2486, Membrane glycoprotein gp140
Accession Q9H5V8-1
Amino Acid Sequence

Phe30-Thr667 with His Tag at the C-Terminus
Expression System HEK293
Molecular Weight 100-120kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Chiu KL, Lin YS, Kuo TT, Lo CC, Huang YK, Chang HF, Chuang EY, Lin CC, Cheng WC, Liu YN, Lai LC, Sher YP. ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis. Oncotarget. 2017 Jul 18;8(29):47365-47378.
2.Zhang L, Wu Y, Li S, Guo M, Zhao J, Cao C, Zhang Y, Xiao H. Proteomic Analysis of Extracellular Vesicles Identifies CDCP1 as Critical Metastasis-Related Glycoprotein in Lung Cancer. J Extracell Vesicles. 2025 Jul;14(7):e70128. 

Background

CDCP1 (CUB Domain Containing Protein 1, also known as SIMA135 or TRASK) is a single-pass transmembrane glycoprotein featuring three extracellular CUB domains and proteolytic cleavage sites; its intracellular segment activates Src family kinases (SFKs) via Y734 phosphorylation, thereby regulating cell adhesion, motility, and anoikis resistance. This protein can bind to integrin β1 to activate FAK/PI3K/Akt signaling and functions as a hypoxia-inducible factor-2α (HIF-2α) target gene under hypoxic regulation; in breast cancer and renal cell carcinoma, CDCP1 drives metastasis through promoting fatty acid oxidation and hypoxic adaptation, respectively. Clinical studies demonstrate that CDCP1 is highly expressed in melanoma, pancreatic cancer, prostate cancer, and other solid tumors, correlating with poor patient prognosis and castration-resistant prostate cancer progression, establishing it as a potential prognostic biomarker and therapeutic target, with anti-CDCP1 antibodies (such as 4A06) currently being investigated for theranostic targeted therapy applications, offering novel precision intervention strategies for metastatic malignancies.

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SKU: 96004785978

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Masked Reviewer
Phoenix, US
★★★★★ 5
Gets the Creative Juices Flowing
Format: Paperback
I picked up this book after hearing Kim Addonizio give a reading at my college when I was an undergraduate. Creative Writing and poetry were my areas of emphasis and although we used a different textbook in my poetry class, I came to love this one. It won't give you the formal training in meter and poetic forms that another textbook might, but I love the examples and the prompts for inspiration. It's my favorite book to turn to when I feel the creative well is running dry. It's warm and funny and you feel a real presence from the authors as if you have teachers with you. I haven't met Dorianne Laux, but I have chatted with Kim Addonizio twice after readings and she was lovely. (Her readings are fantastic, by the way, and I highly recommend them!) If you are familiar with Kim Addonizio'ss poems then you shouldn't be surprised to find a section on erotic poetry in this book. Erotic poems have a long tradition in poetry and they are not "porn" as one reviewer suggested. Sexuality and sensuality are part of life and the artistic expression of such is a special skill set. I think it's fantastic that this book doesn't sensor that. I love the examples chosen for this book--many beautiful, contemporary poems that utilize vivid and unexpected imagery. I find them inspiring. They make me want to write and they make me want to be a better writer. I do believe that if you are a beginner or if you are considering this book as a textbook for a class you should consider it as a supplement to a book that goes into a little more depth in certain areas, such as Writing Poems (see if you can get an older edition, if you are lucky, as I see this book has become quite expensive). But this is a fantastic little book and I love having both a hard copy to underline and put notes in and a Kindle copy to keep with me on my phone so I can have a little inspiration with me for easy access. No matter where you are in your journey as a poet, I believe this is a wonderful book to have in your library.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 31, 2021
K
Verified Purchase
Kasey P.
Boise, US
★★★★★ 5
Received brand new book in perfect condition for less than ten dollars
Format: Paperback
Received brand new book in perfect condition for less than ten dollars. I needed this exact book for a creative writing course and I enjoy the exercises within the different sections. They are very thought provoking and creativity stimulating and would be excellent inspiration for any poetic or even descriptive writer. Also, I find the writing style of the author amazingly easy to read. It is simple and straightforward, easy to follow and not boring as some other texts are. The tone is inspirational honestly, always providing tips and writing encouragement. This is a nice positive twist and delightful different perspective for aspiring writers and though it sounds to be directed at amateurs, I think any author who may experience writer's block at times could find this useful and full of insight to try out fresh perspectives to pen about topics that may be applied to a broad range of subjects. Quality informative and yet uplifting text regarding poetic writing!
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Reviewed in the United States on January 28, 2017
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Marianne
Waukegan, US
★★★★★ 5
Practical, Useful, Down to Earth, Inspiring!
Format: Paperback
I love this book. After reading the first chapter early one morning I went outside to feed and water my cats and came in and wrote a poem about flowing water, tangled morning glories and memories of my mother. It's one of the most inspiring, practical and encouraging books about writing poetry that I've ever read, and trust me, I've read them all. It has technical information and poems to illustrate each chapter, which is very helpful. The suggestions at the end of each chapter are down to earth and do-able, unlike some books that are just too high-minded for the average person. If you love to write poems and just need some inspiration and a little advice and encouragement, then definitely buy this book. It's worth its weight in gold!
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Reviewed in the United States on July 18, 2005
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Verified Purchase
Cindy Lou Lpn
Port Orchard, US
★★★★★ 4
Took me by surprise 😮
Format: Paperback
The revised part of my review: I do agree with a reviewer; Thomas "Should Have Been Better" Especially his paragraph here: [Unless (like the authors) you think that Sharon Olds' "passing blood and feces and water" and her "stool black with iron pills" (page 234) are high points in the world of modern poetry, you may resist their suggestion to "read all five of her books, for pleasure first, of course, but secondly to examine how she goes about her difficult task" (page 47).] As I have read more, I am reevaluating my own opinions of this book. I still feel it has been helpful, although much of it I would have preferred to have never read! Poor choice of examples to a student indeed! This, is my original review: I thought it was going to be a bunch of lame assignments, well there definitely are some assignments so to speak. I haven't even made it through half of the 1st chapter and I've written 6 or 7 new reflections (which some call poetry)! It digs deep, at least it did for me...pretty personal when you open yourself up to it. Good challenge and good lessons to glean from and grow as a writer. I still plan on keeping this around, probably with a few pages removed.
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Reviewed in the United States on October 1, 2023
A
Verified Purchase
Ann Onomymous
Louisville, US
★★★★★ 5
Arrived in good condition
Format: Paperback
Arrived in good condition
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 27, 2026

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